Arabidopsis KINETOCHORE NULL2 Is an Upstream Component for Centromeric Histone H3 Variant cenH3 Deposition at Centromeres
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چکیده
منابع مشابه
Arabidopsis kinetochore null2 is an upstream component for centromeric histone H3 variant cenH3 deposition at centromeres.
The centromeric histone H3 variant cenH3 is an essential centromeric protein required for assembly, maintenance, and proper function of kinetochores during mitosis and meiosis. We identified a kinetochore null2 (KNL2) homolog in Arabidopsis thaliana and uncovered features of its role in cenH3 loading at centromeres. We show that Arabidopsis KNL2 colocalizes with cenH3 and is associated with cen...
متن کاملPutting the cenH3 in the Centromere: Arabidopsis KINETOCHORE NULL2 Acts Upstream of cenH3 Deposition
Imagine yourself as a chromatin-crawling nano-robot—Your mission: to explore the Arabidopsis thaliana centromere. If you ventured from the euchromatin, through the heterochromatin, into the centromere, you would find yourself in a strange place. Even the histones are different, with the familiar H3 replaced by the centromerespecific histone cenH3 (reviewed in De Rop et al., 2012). Mission contr...
متن کاملPutting the cenH3 in the centromere: Arabidopsis kinetochore null2 acts upstream of cenH3 deposition.
Imagine yourself as a chromatin-crawling nano-robot—Your mission: to explore the Arabidopsis thaliana centromere. If you ventured from the euchromatin, through the heterochromatin, into the centromere, you would find yourself in a strange place. Even the histones are different, with the familiar H3 replaced by the centromerespecific histone cenH3 (reviewed in De Rop et al., 2012). Mission contr...
متن کاملA Tale of Two CENPCs: Centromere Localization of KINETOCHORE NULL2 and CENP-C.
Although we have long known the repetitive nature of the DNA in plant and animal centromeres of plant and animals and have identified hundreds of kinetochore proteins, closing the mechanistic gap between the centromereDNAand thekinetochoreprotein complex has remained a challenge. Much research has focused on the centromeric histone cenH3, as cenH3-containing nucleosomes may provide a mark for f...
متن کاملLoss of centromeric histone H3 (CENH3) from centromeres precedes uniparental chromosome elimination in interspecific barley hybrids.
Uniparental chromosome elimination occurs in several interspecific hybrids of plants. We studied the mechanism underlying selective elimination of the paternal chromosomes during the early development of Hordeum vulgare × Hordeum bulbosum embryos. The following conclusions regarding the role of the centromere-specific histone H3 variant (CENH3) in the process of chromosome elimination were draw...
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ژورنال
عنوان ژورنال: The Plant Cell
سال: 2013
ISSN: 1040-4651,1532-298X
DOI: 10.1105/tpc.113.114736